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mainXTALem (MAIN) structure determination: from initial phases to the final structure

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main4XTAL&em / MAIN4xtal&EM (MAIN) is a computer program dealing with computational aspects of macromolecular structure determination used the areas of macromolecular crystallography and electron microscopy. It is usually run through an interactive interface. With MAIN4XTAL&EM a user can

  • visualize molecular models and electron density maps using a 3D graphics interface,
  • build and rebuilding molecular structures using automated and manual tools,
  • modify electron density maps (solvent flattening and flipping, envelopes manipulation, averaging, filtering noise),
  • refine structures using real and reciprocal space targets,
  • analyze and validate structural models

p.s. The name of the program had to be changed to "main4XTAL&em" as Google at some point failed to find it with "main crystallography"